Deep Brain Stimulation for Gilles de la Tourette Syndrome: Toward Limbic Targets. Servello D, Galbiati TF, Balestrino R, Iess G, Zekaj E, Michele S, Porta M. Brain Sci. 2020 May 15;10(5):301.

SUMMARY: Retrospective study comparing results obtained from DBS in the Voi-Cm/Pf (41 patients) and antero-medial Globus Pallidus internus (am-GPi) (14 patients), over a period of 48 months, showing a stable improvement in the YGTSS and YBOCS in both groups (p …

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A Systematic Review of Deep Brain Stimulation Targets for Obsessive Compulsive Disorder. Nataly Raviv, Michael D Staudt, Andrew K Rock, Jacquelyn MacDonell, Julia Slyer, Julie G Pilitsis. Neurosurgery 2020 Jul 2;87(6):1098-1110.

SUMMARY In OCD DBS, multiple targets have been investigated. OBJECTIVE: To systematically review the current level and quality of evidence supporting OCD-DBS by target region with the goal of establishing a common nomenclature. 28 articles were included for review. Articles …

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Efficacy, Effect on Mood Symptoms, and Safety of Deep Brain Stimulation in Refractory Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis. Martinho FP, Duarte GS, Couto FSD. J Clin Psychiatry. 2020 May 26;81(3):19r12821.

SUMMARY: Eight randomized controlled trials (RCTs) (n = 85) and 38 observational studies (case reports and case series) (n = 225) were included. In RCTs, mean differences between sham and active stimulation in Y-BOCS and Hamilton Depression Rating Scale (HDRS) …

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Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, prospective, observational cohort. Chabardes S, Krack P, Piallat B, Bougerol T, Seigneuret E, Yelnik J, Fernandez Vidal S, David O, Mallet L, Benabid AL, Polosan M. J Neurol Neurosurg Psychiatry. 2020 Dec;91(12):1349-1356.

SUMMARY: 19 OCD patients with DTN DBS evaluated at 24 months using YBOCS and GAF. At a 24-month mean YBOCS score improved by 53.4% from 33.3±3.5 to 15.8±9.1. 14 out of 19 patients were considered as responders, 5 out of …

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Efficacy and Safety of Gamma Ventral Capsulotomy for Treatment-Resistant Obsessive-Compulsive Disorder: A Single-Center Experience. Peker S, Samanci MY, Yilmaz M, Sengoz M, Ulku N, Ogel K. World Neurosurg. 2020 Sep;141:e941-e952.

SUMMARY: Gamma ventral capsulotomy (GVC) in 21 patients with OCD. Mean follow-up 60.7 months. YBOCS 35.7 decreased to 15.3 at 36 months follow-up. 15 patients (75%) achieved a full response. Of those patients, 7 (35%) were considered to be in …

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Optimizing Deep Brain Stimulation Parameters in Obsessive-Compulsive Disorder. van Westen M, Rietveld E, Bergfeld IO, de Koning P, Vullink N, Ooms P, Graat I, Liebrand L, van den Munckhof P, Schuurman R, Denys D. Neuromodulation. 2020 Jul 20. doi: 10.1111/ner.13243. Online ahead of print.

SUMMARY: More than 80 OCD DBS patients since 2005: guiding principles for optimizing DBS stimulation parameters in OCD. Adjustments in stimulation parameters are performed in a fixed order. First, electrode contact activation is determined by the position of the electrodes …

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The Impact of Deep Brain Stimulation on the Sexual Function of Patients With Parkinson’s Disease. Pedro T, Sousa M, Rito M, Pereira R, Januário C, Moreira F. Neurologist. 2020 May;25(3):55-61.

SUMMARY:21 patients with PD submitted to STN DBS compared with 19 eligible surgery candidates. Clinical measures included Hoehn and Yahr scale, UPDRS III, PDQ39, Becks Depressive  inventory, and sexual function evaluation (Female Sexual Function Index and International Index of Erectile …

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Subthalamic nucleus deep brain stimulation with a multiple independent constant current-controlled device in Parkinson’s disease (INTREPID): a multicentre, double-blind, randomised, sham-controlled study. Vitek JL, Jain R, Chen L, Tröster AI, Schrock LE, House PA, Giroux ML, Hebb AO, Farris SM, Whiting DM, Leichliter TA, Ostrem JL, San Luciano M, Galifianakis N, Verhagen Metman L, Sani S, Karl JA, Siddiqui MS, Tatter SB, Ul Haq I, Machado AG, Gostkowski M, Tagliati M, Mamelak AN, Okun MS, Foote KD, Moguel-Cobos G, Ponce FA, Pahwa R, Nazzaro JM, Buetefisch CM, Gross RE, Luca CC, Jagid JR, Revuelta GJ, Takacs I, Pourfar MH, Mogilner AY, Duker AP, Mandybur GT, Rosenow JM, Cooper SE, Park MC, Khandhar SM, Sedrak M, Phibbs FT, Pilitsis JG, Uitti RJ, Starr PA. Lancet Neurol. 2020 Jun;19(6):491-501.

SUMMARY: Double-blind, sham-controlled, randomized multicenter (23 centers) trial STN DBS using BSc electrodes. 160 Patients were randomly assigned to receive either active therapeutic stimulation settings (active group) or subtherapeutic stimulation settings (control group) for the 3-month blinded period. The primary …

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Dementia and subthalamic deep brain stimulation in Parkinson disease: A long-term overview. Francesco Bove, Valerie Fraix, Francesco Cavallieri, Emmanuelle Schmitt, Eugénie Lhommée, Amélie Bichon, Sara Meoni, Pierre Pélissier, Andrea Kistner, Eric Chevrier, Claire Ardouin, Patricia Limousin, Paul Krack , Alim Louis Benabid, Stephan Chabardès, Eric Seigneuret, Anna Castrioto, Elena Moro. Neurology 2020 Jul 28;95(4):e384-e392.

SUMMARY: To assess the prevalence and the cumulative incidence of dementia at short-, medium- and long-term (1, 5, and 10 years) follow-up after STN DBS and to evaluate potential risk factors for postoperative dementia. A total of 175 patients were …

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Acute effects of adaptive Deep Brain Stimulation in Parkinson’s disease. Piña-Fuentes D, van Dijk JMC, van Zijl JC, Moes HR, van Laar T, Oterdoom DLM, Little S, Brown P, Beudel M. Brain Stimul. 2020 Jul 29;13(6):1507-1516.

SUMMARY: Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson’s disease (PD), when assessed in the immediate post-implantation phase. However, the potential benefits of aDBS in patients with electrodes chronically implanted, in whom changes due to the microlesion effect …

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