Acute effects of adaptive Deep Brain Stimulation in Parkinson’s disease. Piña-Fuentes D, van Dijk JMC, van Zijl JC, Moes HR, van Laar T, Oterdoom DLM, Little S, Brown P, Beudel M. Brain Stimul. 2020 Jul 29;13(6):1507-1516.

SUMMARY: Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in Parkinson’s disease (PD), when assessed in the immediate post-implantation phase. However, the potential benefits of aDBS in patients with electrodes chronically implanted, in whom changes due to the microlesion effect …

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Effect of Cycling Thalamosubthalamic Stimulation on Tremor Habituation and Rebound in Parkinson Disease. Enatsu R, Kitagawa M, Morishita T, Sasagawa A, Kuribara T, Hirano T, Arihara M, Mikami T, Mikuni N. World Neurosurg. 2020 Dec;144:64-67.

SUMMARY: The authors assessed the effects of different temporal patterns of cycling stimulation of posterior subthalamic area, subthalamic nucleus and the ventral intermediate nucleus of the thalamus in three PD patients with early decline of tremor suppression associated with severe …

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Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease. Paff M, Loh A, Sarica C, Lozano AM, Fasano A. J Mov Disord. 2020 Sep;13(3):185-198.

SUMMARY: Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current …

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Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor. Eisinger RS, Wong J, Almeida L, Ramirez-Zamora A, Cagle JN, Giugni JC, Ahmed B, Bona AR, Monari E, Wagle Shukla A, Hess CW, Hilliard JD, Foote KD, Gunduz A, Okun MS, Martinez-Ramirez D. Mov Disord Clin Pract. 2017 Nov 27;5(1):75-82.

SUMMARY: To compare clinical outcomes and DBS programming at 4 years between VIM and cZI DBS in ET-DBS patients, a retrospective review of 53 DBS leads from 47 patients was performed. Although improvement was still significant at 4 years, scores …

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Deep Brain Stimulation in Parkinson’s Disease: Still Effective After More Than 8 Years. Birgitte L C Thomsen, Steen R Jensen, Anders Clausen, Merete Karlsborg, Bo Jespersen, Annemette Løkkegaard. Mov Disord Clin Pract 2020 Sep 21;7(7):788-796.

SUMMARY: The aim was to examine the long-term effects of STN-DBS in PD and evaluate the effect of reprogramming after more than 8 years of treatment. Methods: A total of 82 patients underwent surgery in Copenhagen between 2001 and 2008. …

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EUROPAR and the IPMDS Non Motor PD Study Group. Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease. Dafsari HS, Dos Santos Ghilardi MG, Visser-Vandewalle V, Rizos A, Ashkan K, Silverdale M, Evans J, Martinez RCR, Cury RG, Jost ST, Barbe MT, Fink GR, Antonini A, Ray-Chaudhuri K, Martinez-Martin P, Fonoff ET, Timmermann LBrain Stimul. 2020 Oct 7;13(6):1697-1705.

SUMMARY: To compare nonmotor effects of STN-DBS and GPi-DBS. Observational, multicenter study including 60 PD patients undergoing bilateral STN-DBS (40) or GPi-DBS (20) were compared using PDQ 39, NMSS), UPDRS, Hoehn&Yahr, Schwab&England Scale, and levodopa-equivalent daily dose (LEDD) preop and …

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Endurance of Short Pulse Width Thalamic Stimulation Efficacy in Intention Tremor. Wirth T, Dayal V, de Roquemaurel A, Ferreira F, Vijiaratnam N, Akram H, Zrinzo L, Foltynie T, Limousin P. Stereotact Funct Neurosurg. 2020 Nov 23:1-6.

SUMMARY: The benefit of short pulse width DBS in ET patients remains controversial. We report the effect of this type of stimulation in 3 patients with a persistent and severe intention tremor component despite iterative DBS setting adjustments. While a …

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A Phase 2 Randomized Trial of Asleep versus Awake Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease. Engelhardt J, Caire F, Damon-Perrière N, Guehl D, Branchard O, Auzou N, Tison F, Meissner WG, Krim E, Bannier S, Bénard A, Sitta R, Fontaine D, Hoarau X, Burbaud P, Cuny E. Stereotact Funct Neurosurg. 2020 Nov 30:1-11.

SUMMARY: Prospective, randomized trial to assess the motor outcomes of asleep DBS. Leads were implanted in the subthalamic nucleus (STN) according to probabilistic stereotactic coordinates with a surgical robot under O-arm imaging guidance under either general anesthesia without microelectrode recordings …

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Deep Brain Stimulation Selection Criteria for Parkinson’s Disease: Time to Go beyond CAPSIT-PD. Artusi CA, Lopiano L, Morgante F. J Clin Med. 2020 Dec 4;9(12):E3931

SUMMARY: Despite being introduced in clinical practice more than 20 years ago, selection criteria for deep brain stimulation (DBS) in Parkinson’s disease (PD) rely on a document published in 1999 called ‘Core Assessment Program for Surgical Interventional Therapies in Parkinson’s …

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Upcoming meetings in 2021

Some opportunities to catch up on the latest developments in the field 2021 North American Neuromodulation Society Virtual Meeting, January 15 – 16, 2021. 2nd Joint Congress of the INS European Chapters, Paris France, September 2- 4, 2021. European Society …

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