Reduced Programming Time and Strong Symptom Control Even in Chronic Course Through Imaging-Based DBS Programming. Lange F, Steigerwald F, Malzacher T, Brandt GA, Odorfer TM, Roothans J, Reich MM, Fricke P, Volkmann J, Matthies C, Capetian PD. Front Neurol. 2021 Nov 8;12:785529.

SUMMARY: 10 Parkinson’s disease patients with subthalamic nucleus-DBS were randomly assigned to standard clinical-based programming (CBP) or anatomical-based (imaging-guided) programming (ABP) in an 8-week crossover trial. Programming characteristics and clinical outcomes were evaluated. Both programs led to similar motor symptom …

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Imaging-based programming of subthalamic nucleus deep brain stimulation in Parkinson’s disease. Waldthaler J, Bopp M, Kühn N, Bacara B, Keuler M, Gjorgjevski M, Carl B, Timmermann L, Nimsky C, Pedrosa DJ. Brain Stimul. 2021 Sep-Oct;14(5):1109-1117.

SUMMARY: The need for imaging-guided optimization of Deep Brain Stimulation (DBS) parameters is increasing with recent developments of sophisticated lead designs offering highly individualized, but time-consuming and complex programming. The objective of this study was to compare changes in motor …

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Single-Trajectory Multiple-Target Deep Brain Stimulation for Parkinsonian Mobility and Cognition. Sasikumar S, Cohn M, Harmsen IE, Loh A, Cho SS, Sáenz-Farret M, Maciel R, Soh D, Boutet A, Germann J, Elias G, Youm A, Duncan K, Rowland NC, Strafella AP, Kalia SK, Lozano AM, Fasano A. Mov Disord. 2021 Nov 22. doi: 10.1002/mds.28870. Online ahead of print.

SUMMARY: The aim of this study is to achieve feasibility and safety of globus pallidus pars interna (GPi) and Nucleus Basalis of Meynert (NBM) DBS in advanced PD with cognitive impairment. The authors performed a phase-II double-blind crossover pilot trial …

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Distribution of electric field in patients with obsessive compulsive disorder treated with deep brain stimulation of the bed nucleus of stria terminalis. Naesström M, Johansson J, Hariz M, Bodlund O, Wårdell K, Blomstedt P. Acta Neurochir (Wien). 2021 Oct 15. doi: 10.1007/s00701-021-04991-0. Online ahead of print.

SUMMARY: In a pilot study of 11 participants with DBS of the BNST, the authors investigate through patient-specific simulation of electric field, which anatomical areas are affected by the electric field, and if this can be related to the clinical …

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A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Mosley PE, Windels F, Morris J, Coyne T, Marsh R, Giorni A, Mohan A, Sachdev P, O’Leary E, Boschen M, Sah P, Silburn PA. Transl Psychiatry. 2021 Mar 29;11(1):190.

SUMMARY: Nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with DBS electrodes bilaterally in the bed nucleus of the stria terminalis (BNST). Following a one-month postoperative recovery phase, participants entered a three-month randomised, double-blind, sham-controlled phase …

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Deep Brain Stimulation of the Substantia Nigra Pars Reticulata for Treatment-Resistant Schizophrenia: A Case Report. Cascella N, Butala AA, Mills K, Kim MJ, Salimpour Y, Wojtasievicz T, Hwang B, Cullen B, Figee M, Moran L, Lenz F, Sawa A, Schretlen DJ, Anderson W. Biol Psychiatry. 2021 Nov 15;90(10):e57-e59.

SUMMARY: First case showing that SNr DBS in resistant schizophrenia can be safely used and can provide relief from symptoms. Rational for this procedure is given by the authors as follows: “The substantia nigra pars reticulata (SNr) functions as a …

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Deep Brain Stimulation in the Bed Nucleus of Stria Terminalis in Obsessive-Compulsive Disorder-1-Year Follow-up. Naesström M, Hariz M, Strömsten L, Bodlund O, Blomstedt P. World Neurosurg. 2021 May;149:e794-e802.

SUMMARY: 11 consecutive participants with refractory OCD were treated with BNST DBS. At baseline, the mean YBOCS score was 33, MADRS score was 29, and GAF score was 49. One year after DBS, mean YBOCS score was 20 (38% improvement), …

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Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder. Baldermann JC, Schüller T, Kohl S, Voon V, Li N, Hollunder B, Figee M, Haber SN, Sheth SA, Mosley PE, Huys D, Johnson KA, Butson C, Ackermans L, Bouwens van der Vlis T, Leentjens AFG, Barbe M, Visser-Vandewalle V, Kuhn J, Horn A. Biol Psychiatry. 2021 Nov 15;90(10):678-688.

SUMMARY: There is ambiguity about the best suited target for DBS and insufficient knowledge about underlying mechanisms. Recent advances suggest that changes in broader brain networks are responsible for improvement of obsessions and compulsions, rather than local impact at the …

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Long-term Outcome of Deep Brain Stimulation of the Ventral Part of the Anterior Limb of the Internal Capsule in a Cohort of 50 Patients With Treatment-Refractory Obsessive-Compulsive Disorder. Graat I, Mocking R, Figee M, Vulink N, de Koning P, Ooms P, Mantione M, van den Munckhof P, Schuurman R, Denys D. Biol Psychiatry. 2021 Nov 15;90(10):714-720.

SUMMARY: 50 patients with severe treatment-refractory OCD received DBS of the ventral part of the anterior limb of the internal capsule and were followed for at least 3 (mean 6.8) years. Adverse effects of DBS were examined with a structured …

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Deep Brain Stimulation of the Nucleus Accumbens, Ventral Striatum, or Internal Capsule Targets for Medication-Resistant Obsessive-Compulsive Disorder: A Multicenter Study. Torres Díaz CV, Treu S, Strange B, Lara M, Navas M, Ezquiaga E, Zazo ES, Vicente JS, Muñiz I, Fernandez FS. World Neurosurg. 2021 Nov;155:e168-e176.

SUMMARY: 14 patients were operated on under the same protocol. 11 showed significant improvement in obsessive-compulsive disorder symptoms (reduction 35% in Y-BOCS). Seven patients responded to stimulation at the nucleus accumbens whereas 4 patients needed to have the active contact …

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