SUMMARY: There is ambiguity about the best suited target for DBS and insufficient knowledge about underlying mechanisms. Recent advances suggest that changes in broader brain networks are responsible for improvement of obsessions and compulsions, rather than local impact at the …
SUMMARY: 50 patients with severe treatment-refractory OCD received DBS of the ventral part of the anterior limb of the internal capsule and were followed for at least 3 (mean 6.8) years. Adverse effects of DBS were examined with a structured …
SUMMARY: 14 patients were operated on under the same protocol. 11 showed significant improvement in obsessive-compulsive disorder symptoms (reduction 35% in Y-BOCS). Seven patients responded to stimulation at the nucleus accumbens whereas 4 patients needed to have the active contact …
SUMMARY: DBS for major depression could be optimized by identifying neural biomarkers that trigger therapy selectively when symptom severity is elevated. The authors developed an approach that first used multi-day intracranial electrophysiology and focal electrical stimulation to identify a personalized …
SUMMARY: While comparing studies on asleep and awake DBS, one should keep in mind that the level of consciousness of the patient is just one factor at play. Differences in the surgical methods (or + physiology), the applied imaging, and …
SUMMARY: A substantial majority of patients in the United States still undergo multiple, “staged” surgeries to implant a DBS system. Despite several reports suggesting no significant difference in complications or efficacy between staged and non-staged approaches, the continued use of …
SUMMARY: Prospective randomized open-label blinded end point clinical trial. Primary outcome follow-up visit 6 months after DBS. Bilateral STN DBS was performed under general anesthesia in 1 study arm and awake in the other study arm. Both with MER. The …
SUMMARY: This study compares the outcomes between patients who underwent VIM DBS with direct and indirect targeting. 230 patients underwent VIM DBS, 92 had direct targeting (direct visualization on proton density 3-T MRI), 138 had indirect targeting (relative to the …
SUMMARY: Assessing the large number of possible stimulation settings (i.e., programming) requires numerous clinic visits. The authors examine whether functional magnetic resonance imaging (fMRI) can be used to predict optimal stimulation settings for individual patients. They analyze 3 T fMRI …
SUMMARY: 51 patients with 17.06 ± 2.18 years STN-DBS follow-up were recruited. Compared to baseline, the time spent with dyskinesia and the time spent in the off state were reduced by 75% and by 58.7%, respectively. Dopaminergic drugs were reduced …