SUMMARY: The authors investigated the hemorrhagic risk associated with radiofrequency (RF) ablation on ventro-oral (Vo) nucleus, ventral intermediate (Vim) nucleus, GPi, and pallidothalamic tract (PTT) between 2012 to 2019 on 558 patients (356 dystonia, 111 essential tremor (ET) , 51 …
SUMMARY: a prospective, single-arm, single-blinded phase 2 trial of second-side magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy in 10 patients with essential tremor who were followed for 3 months. The primary outcome was the change in quality of life relative to …
SUMMARY: 5 consecutive patients with refractory essential tremor underwent a second Alexanderasymmetrically to the first lesion. The second lesion center was superior to the first lesion in all patients. The mean baseline, second preoperative, and second postoperative Clinical Rating Scale …
SUMMARY: 10 Parkinson’s disease patients with subthalamic nucleus-DBS were randomly assigned to standard clinical-based programming (CBP) or anatomical-based (imaging-guided) programming (ABP) in an 8-week crossover trial. Programming characteristics and clinical outcomes were evaluated. Both programs led to similar motor symptom …
SUMMARY: The need for imaging-guided optimization of Deep Brain Stimulation (DBS) parameters is increasing with recent developments of sophisticated lead designs offering highly individualized, but time-consuming and complex programming. The objective of this study was to compare changes in motor …
SUMMARY: The aim of this study is to achieve feasibility and safety of globus pallidus pars interna (GPi) and Nucleus Basalis of Meynert (NBM) DBS in advanced PD with cognitive impairment. The authors performed a phase-II double-blind crossover pilot trial …
SUMMARY: In a pilot study of 11 participants with DBS of the BNST, the authors investigate through patient-specific simulation of electric field, which anatomical areas are affected by the electric field, and if this can be related to the clinical …
SUMMARY: Nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with DBS electrodes bilaterally in the bed nucleus of the stria terminalis (BNST). Following a one-month postoperative recovery phase, participants entered a three-month randomised, double-blind, sham-controlled phase …
SUMMARY: First case showing that SNr DBS in resistant schizophrenia can be safely used and can provide relief from symptoms. Rational for this procedure is given by the authors as follows: “The substantia nigra pars reticulata (SNr) functions as a …
SUMMARY: 11 consecutive participants with refractory OCD were treated with BNST DBS. At baseline, the mean YBOCS score was 33, MADRS score was 29, and GAF score was 49. One year after DBS, mean YBOCS score was 20 (38% improvement), …