SUMMARY: In a pilot study of 11 participants with DBS of the BNST, the authors investigate through patient-specific simulation of electric field, which anatomical areas are affected by the electric field, and if this can be related to the clinical …
SUMMARY: Nine participants (four females, mean age 47.9 ± 10.7 years) were implanted with DBS electrodes bilaterally in the bed nucleus of the stria terminalis (BNST). Following a one-month postoperative recovery phase, participants entered a three-month randomised, double-blind, sham-controlled phase …
SUMMARY: First case showing that SNr DBS in resistant schizophrenia can be safely used and can provide relief from symptoms. Rational for this procedure is given by the authors as follows: “The substantia nigra pars reticulata (SNr) functions as a …
SUMMARY: 11 consecutive participants with refractory OCD were treated with BNST DBS. At baseline, the mean YBOCS score was 33, MADRS score was 29, and GAF score was 49. One year after DBS, mean YBOCS score was 20 (38% improvement), …
SUMMARY: There is ambiguity about the best suited target for DBS and insufficient knowledge about underlying mechanisms. Recent advances suggest that changes in broader brain networks are responsible for improvement of obsessions and compulsions, rather than local impact at the …
SUMMARY: 50 patients with severe treatment-refractory OCD received DBS of the ventral part of the anterior limb of the internal capsule and were followed for at least 3 (mean 6.8) years. Adverse effects of DBS were examined with a structured …
SUMMARY: 14 patients were operated on under the same protocol. 11 showed significant improvement in obsessive-compulsive disorder symptoms (reduction 35% in Y-BOCS). Seven patients responded to stimulation at the nucleus accumbens whereas 4 patients needed to have the active contact …
SUMMARY: DBS for major depression could be optimized by identifying neural biomarkers that trigger therapy selectively when symptom severity is elevated. The authors developed an approach that first used multi-day intracranial electrophysiology and focal electrical stimulation to identify a personalized …
SUMMARY: While comparing studies on asleep and awake DBS, one should keep in mind that the level of consciousness of the patient is just one factor at play. Differences in the surgical methods (or + physiology), the applied imaging, and …
SUMMARY: A substantial majority of patients in the United States still undergo multiple, “staged” surgeries to implant a DBS system. Despite several reports suggesting no significant difference in complications or efficacy between staged and non-staged approaches, the continued use of …