SUMMARY: Prospective randomized open-label blinded end point clinical trial. Primary outcome follow-up visit 6 months after DBS. Bilateral STN DBS was performed under general anesthesia in 1 study arm and awake in the other study arm. Both with MER. The …
SUMMARY: This study compares the outcomes between patients who underwent VIM DBS with direct and indirect targeting. 230 patients underwent VIM DBS, 92 had direct targeting (direct visualization on proton density 3-T MRI), 138 had indirect targeting (relative to the …
SUMMARY: Assessing the large number of possible stimulation settings (i.e., programming) requires numerous clinic visits. The authors examine whether functional magnetic resonance imaging (fMRI) can be used to predict optimal stimulation settings for individual patients. They analyze 3 T fMRI …
SUMMARY: 51 patients with 17.06 ± 2.18 years STN-DBS follow-up were recruited. Compared to baseline, the time spent with dyskinesia and the time spent in the off state were reduced by 75% and by 58.7%, respectively. Dopaminergic drugs were reduced …
SUMMARY: In 30 ET patients undergoing bilateral DBS, severity of tremor was assessed by blinded video ratings before and at 1-year follow-up with DBS ON and OFF. Tremor scores and reported side effects and volumes of tissue activated were used …
SUMMARY: In Parkinson’s disease, both motor and neuropsychiatric complications unfold as consequence of both incremental striatal dopaminergic denervation and intensifying long-term dopaminergic treatment. Together, this leads to ‘dopaminergic sensitization’ steadily increasing motor and behavioral responses to dopaminergic medication that result …
SUMMARY: 13 patients with levodopa-unresponsive gait disturbance. Patients were evaluated before (on-medication condition) and 1 yr after surgery (on-medication-on-stimulation condition), assessing gait, balance, postural instability, and falls. Surgery improved balance by 43% reduced FOG by 35% , and the monthly …
SUMMARY: 124 patients undergoing STN-DBS evaluated based on the video-documented Levodopa test at baseline in the OFF- and ON-drug condition and postoperatively in the best condition (ON-drug/ON-stim) and the worst condition (OFF-drug/ON-stim). The authors compared the freezing item of the …
SUMMARY: The depletion of implantable pulse generator (IPG) battery and the associated sudden recurrence of PD or dystonia symptoms, can be potentially life-threatening. The databases of PubMed, Scopus, EMBASE and Google Scholar resulted in 12 papers presented with a total …
SUMMARY: Instead of homogenizing data to a reference, the authors measured how accurately electrodes are implanted relative to an ideal, dorsal STN stimulation location, assessed on each individual’s native imaging. There were 226 electrodes in 113 consecutive PD patients implanted …